Job Description

The Process Chemistry team, part of the CMC Synthetics organization within Sanofi R&D, is responsible for the design and preliminary process development of commercial manufacturing routes for drug substances undergoing clinical development. We strongly believe that innovation is an important driver to be successful and we focus a large part of our activity on developing new synthetic routes, concepts, and technologies to provide drug substances in the most efficient, robust, economical, environmentally benign, and intrinsically safe way. We are looking for a highly motivated and collaborative individual with expertise in synthetic organic chemistry to join our Process Chemistry team. Under the direction of Process Chemistry leadership, the primary responsibility of this role is to perform and oversee multi-step route evaluation and route development activities, with the aim of establishing commercial drug substance manufacturing processes through management and execution of internal and outsourced laboratory activities. Depending on projects, this role may also oversee the activities of one or more collaborators. In this role you will: Design novel synthetic pathway for drug substances in clinical development. Conduct route scouting in laboratory to demonstrate synthetic viability. Use all imaginable chemistry tools and methods to develop new synthetic pathways (photochemistry, biochemistry, flow chemistry, electrochemistry, on-line analysis, High Throughput Screening, structural analysis (NMR, UPLC/MS). Analyze experimental data to drive synthetic experimental plans. Assist in the design, planning and execution of multi-step experimental studies guided by risk assessment to deliver safe, efficient, robust and scalable drug substance manufacturing processes. Investigate optimization and scale-up of reaction and purification unit operations. Collaborate within project teams by working closely with analytical chemists, process engineers, pilot plant experts and project managers within the CMC Synthetics organization. Communicate scientific results in a clear, concise, and accurate manner via electronic laboratory notebook documentation, development reports, project discussions and presentations. Draft and review technical reports, external publications and patent applications. May include management of outsourced laboratory activities: generating scope of work, supervising activities at CDMOs, validating reports for outsourced activities. About you: Ph.D. in organic or synthetic chemistry. Knowledge in at least one of the following areas: advanced analytics, flow chemistry, high throughput experimentation. Experience in chemocatalysis or biocatalysis including characterization of catalytic processes and/or mechanistic analysis. Computational capabilities and basic coding skills. Strong publication record in peer-reviewed journals. Excellent written and verbal communication skills. Ability to operate with flexibility in a dynamic environment and with tight deadlines. Post-doctoral experience. Proficiency with Microsoft suite. Familiarity with digital tools (e.g. Scifinder-n, and Reaxys) and advanced data analysis software (e.g. Spotfire). Design of experiment, statistical and/or thermo-kinetic modeling. Strategic and innovative thinker with a track record of fresh insightful thinking by developing creative approaches to processes and practices. French language skills. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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